Following the execution of Anne Boleyn, King Henry VIII takes Jane Seymour as his third wife, convinced she is the woman destined to bear him a son. Though Jane's pregnancy is cause to rejoice, Henry faces mounting threats to his authority from a commoners' revolt inside England and a Pope in Rome who is determined to stem Protestantism's rise. As attacks on his new church foreshadow trouble for the King, the increasingly powerful Thomas Cromwell redoubles his efforts to crush Catholicism across England. When Jane dies shortly after giving birth to Henry's first son, Cromwell looks to capitalize on the tragedy to find a new wife who will bring with her the alliances needed to stave off a Catholic invasion – only to be undermined by Henry's staunchest supporters. And as an anguished Henry struggles to codify his position as the head of the new church, no one is safe from his growing madness.